C3? Hit. You Sunk My Glomerular Basement Membrane.

GIRLS WHEN THEY RECEIVE COMPLEMENTS GUYS WHEN THEY RECEIVE COMPLEMENTS  KIDNEYS WHEN THEY RECEIVE COMPLEMENTS
*Deposition of complement complexes in the kidney can render as bumpy/puffy appearances in immunofluorescence.

 You probably haven't heard the term glomerular basement membrane since learning about Goodpasture's. There's a ASCP BOC test question for you. 

After learning the coag cascade you thought there couldn't possibly be more cascades to learn? Well buck up sonny, the body has more cascades than the pacific northwest and the complement cascade is no different. Read this article about Complement In Kidney Disease to further your understanding on aHUS (atypical Hemolytic Uremic Syndrome) and C3 glomerulopathy. Then look up Goodpasture's for more kidney destroying fun because it's sure to be on your certification tests. Make sure to differentiate between the 4 types of hypersensitivies! 

The best part about the complement cascade has to be the Membrane Attack Complex. If you're snoring in your seat at the beginning of the complement lecture, you'll instantly awaken with excited energy to learn about the big MAC attack. Molecular/Cell biology is amazing. 

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